Review
Open access
Jul 2026
Targeting molecular and genetic pathways driving tumorigenesis for precision therapy in colorectal cancer
This review examines the foundational signaling mechanisms implicated in CRC, with an emphasis on the Wnt/β-catenin, GUCY2C, MAPK/ERK, p53, PI3K/AKT, and SMAD4/TGF-β pathways.
Allison S. Doermann, Adi Caspi, Andrew E. Evans et al.
· Cancer Biology & Therapy · 0 citations