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Author

Andrea Rivera-Pizana

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Open access Oct 2026

A ribosomal pseudouridine drives an oncogenic translation program

Ribosome heterogeneity can regulate translation, but how changes in ribosome chemistry reshape cellular programs and contribute to diseases such as cancer remains incompletely understood. Here we show that SNORA81-guided pseudouridylation at a single 28S ribosomal RNA site, U4636, links ribosome heterogeneity to select...

Laurence Faucher-Giguère, Andrea Rivera-Pizana, Baudouin Seguineau de Préval et al. · 0 citations
Open access Oct 2026

A ribosomal pseudouridine drives an oncogenic translation program

Dynamic ribosome heterogeneity has emerged as a potential layer of translational regulation, but whether variation in ribosomal RNA (rRNA) modification stoichiometry can selectively control the translation of mRNAs with shared encoded features remains unclear. Here we show that SNORA81-guided pseudouridylation at U4636...

Laurence Faucher-Giguère, Andrea Rivera-Pizana, Baudouin Seguineau de Préval et al. · 0 citations

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