Open access
Sep 2026
MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness.
Extrachromosomal DNA (ecDNA) comprises megabase-sized circular DNA elements that frequently carry oncogene amplifications, driving aggressive tumour phenotypes, therapeutic resistance and poor clinical outcomes across many cancers1-4. Although ecDNA is thought to arise from canonical double-strand break repair, the pat...
David Billing, Monica Selvaraj, M. E. Kelley et al.
· Nature · 0 citations