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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Andreas S. Reichert

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3 papers indexed here

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Open access Oct 2026

Priming of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming and functional impairments in iPSC-derived cardiomyocytes

How Doxorubicin (Dox) mediated damage to stem cells or cardiomyocytes contributes to cardiotoxicity and cardiac regeneration is unclear. Using a human iPSC-based model together with corresponding iPSC-derived cardiomyocytes (iCMs) revealed that iPSCs are much more sensitive against single short pulse-treatments with Do...

Michelle Westerhoff, Roohallah Ghodrat, Nahal Brocke-Ahmadinejad et al. · 0 citations
Open access Sep 2026

Ubp3 mediates dynamic deubiquitination of mitochondria upon induction of mitophagy

Highlights Ubp3 as a prominent rheostat of mitochondrial ubiquitin remodelling are highlighted, revealing mitochondrial ubiquitin storage and its dynamic release as another layer of stress regulation by ubiquitin-dependent quality control pathways.

Kai Mayor Völtzke, Lars Bostelmann-Arp, Christina Behrendt et al. · 0 citations
Open access Aug 2026

In vitro characterization of the baker’s yeast deubiquitinase Ubp3

It is indicated that the catalytic domain alone is sufficient for substrate cleavage, whereas the extensive IDRs of Ubp3 and its cofactor Bre5 might contribute to substrate recognition or specificity, which highlights the importance of intrinsically disordered regions in regulating deubiquitinase function and cellular...

Lars Bostelmann-Arp, S. Khosa, Jens Reiners et al. · 1 citation

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