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Author

Andrei Irimia

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2 papers indexed here

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Open access Sep 2026

Tissue- and compartment-resolved brain age reveals vascular-metabolic and neurodegenerative aging

Brain aging reflects heterogeneous vascular-metabolic and neurodegenerative processes, yet brain age is often reduced to a gray matter (GM)-dominant estimate. Emerging evidence suggests that subtle “dirty-appearing” T2-FLAIR abnormalities may mark diffuse white matter (WM) vulnerability that precedes or extends beyond...

Hosung Kim, Cong Zang, Jin-Soo Lee et al. · 0 citations
Open access Aug 2026

Genome-wide analysis of subcortical aging identifies a spatially structured pattern of genetic associations.

This work presents the first genome-wide association study (GWAS) of subcortical LBA, estimated using a deep neural network applied to T1-weighted MRI scans from 41,957 cognitively normal participants in the UK Biobank, and identifies 14 significant single-nucleotide polymorphisms across nine independent loci.

Nicholas J. Kim, Ayati Mishra, Jeremy S Yu et al. · 0 citations

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