Andrés Herrera-Yela

Deconstructing the Alternative Lengthening of Telomeres: Integromics Prioritizes Five Master Hubs Dictating Clinical Survival and Therapeutic Vulnerabilities

Simple Summary Certain aggressive cancers, such as sarcomas and brain gliomas, achieve cellular “immortality” by lengthening their telomeres using a survival mechanism called ALT. Currently, researchers look for specific DNA mutations to detect ALT, but this method is often insufficient for accurately predicting patien...