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Andrew Folz

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Open access Sep 2026

Cognitive flexibility deficits differ between the sexes in a transchromosomic mouse model of Down syndrome.

Individuals with Down syndrome (DS) exhibit cognitive and behavioral phenotypes, including intellectual disability, and reduced cognitive flexibility. The TcMAC21 DS mouse model (Tc(HSA21,CAG-EGFP)1Yakaz/J) has a freely segregating human chromosome 21 containing ∼93% of protein-coding genes and was hypothesized to show...

Elysabeth Otte, Nicole Gordon, Andrew Folz et al. · 0 citations

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