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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Andrew Hinman

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2 papers indexed here

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Open access Oct 2026

Development of Next-Generation ALDH1B1 Inhibitors with Enhanced Pharmacological and Functional Properties

ALDH1B1 is a mitochondrial aldehyde dehydrogenase required for the survival of stem-like colorectal and pancreatic cancer cells. Isoform-selective guanidinyl antagonists of aldehyde dehydrogenases (IGUANAs) have been developed for ALDH1B1, and here we describe structure−activity relationship (SAR) studies of three sc...

A. Tarhan, Zhi-Ping Feng, Daniel Fernández et al. · 0 citations
Open access Sep 2026

Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels.

Hyponatremia is a prevalent disorder marked by excess water retention and substantial morbidity, motivating interest in the chloride channel CLC-Ka as a therapeutic target. Selectively inhibiting CLC-Ka without affecting the closely related CLC-Kb is essential for preventing serious side effects. However, developing is...

Chih-Ta Chien, Briana L. Sobecks-Doherty, A. Powers et al. · 0 citations

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