Andrew J Stagg

Systemic reprogramming of monocytes in Crohn’s disease promotes their intestinal inflammatory function

Bone marrow–derived circulating monocytes continuously replenish intestinal macrophages, which become dysregulated in inflammatory bowel disease (IBD) and contribute to disease pathology. The origins of this dysregulation remain poorly understood. Here, we investigate the reprogramming of circulating monocytes in IBD p...