Extrachromosomal DNA (ecDNA) comprises megabase-sized circular DNA elements that frequently carry oncogene amplifications, driving aggressive tumour phenotypes, therapeutic resistance and poor clinical outcomes across many cancers1-4. Although ecDNA is thought to arise from canonical double-strand break repair, the pat...
David Billing, Monica Selvaraj, M. E. Kelley et al.· Nature· 0 citations
Reference proteomes incompletely represent proteins translated in cancer, leaving tumor-specific proteoforms outside the search space of conventional mass spectrometry (MS). Such “dark proteome” products may arise from genomic variation, aberrant transcription or splicing, and non-canonical translation, including micro...
L. Schmalbrock, Asher Preska Steinberg, Katarzyna Kulej et al.· bioRxiv· 0 citations
The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models1,2. However, existing collections represent only a fraction of the diversity observed in human cancer2, 3–4. Recent technologies have enabled efficient in vitro model derivation (for example...
Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al.· Nature· 3 citations
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