Author

Andrew P. Gilmore

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Open access Sep 2026

NexuST: A Hierarchical Foundation Model for Spatial Transcriptomics

Spatial transcriptomics captures molecular states within cells and their organisation in tissue. However, integrating fine-grained gene information with spatial context at scale remains challenging for existing foundation models. Here we present NexuST, a hierarchical foundation model that repeatedly interleaves gene-l...

Hai-Ping Liu, Qian Zhao, Li-Jing Lin et al. · bioRxiv · 0 citations

Review Open access Aug 2026

Mitochondrial dynamics and mechanosignalling - Integrating metabolic demand and life-death decisions with microenvironmental mechanics.

The way by which cells sense and interpret their microenvironment is fundamental to the regulation of their behaviour. Mechanosignalling is an essential aspect of microenvironmental sensing by cells, particularly within complex three-dimensional tissues, but it remains unclear how this signalling interacts with and mod...

Fabianna Tennant, Andrew P. Gilmore · Seminars in Cell and Develop... · 0 citations