Author

Andrew R. Bassett

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Open access Oct 2026

Transcriptomic and phenotypic characterization of Alzheimer’s disease risk genes in neurons and astrocytes highlights shared and cell type specific cellular mechanisms

Genome-wide association studies have identified nearly 100 genetic loci that affect Alzheimer’s disease risk. However, there is still a major challenge in linking genetic associations to genes and understanding their downstream cellular mechanisms of action. To address this gap, we performed single-cell transcriptomics...

Caia Dominicus, Diego Peretti, Geraldine Rodschinka et al. · bioRxiv · 0 citations

Open access Jul 2026

SELECT-seq allows Pre-Sequencing Enrichment of SNP Edits in One-Pot Single-Cell Whole-Transcriptome Sequencing

Advances in high-throughput sequencing have associated millions of putative genetic variants with disease. However, scalable experimental methods to establish causal relationships between genetic variants and downstream transcriptional outcomes remain a major challenge. Single-cell methods that integrate genotyping wit...

Sho Iwama, D. Gitterman, Timothy Brendler-Spaeth et al. · bioRxiv · 0 citations