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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

An-gang Yang

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2 papers indexed here

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Open access Sep 2026

Activation-induced cytidine deaminase sustains glycolytic flux through MYST1 acetyltransferase-dependent lactylation in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) exhibits profound metabolic reprogramming, yet the mechanisms that sustain persistent glycolytic flux remain poorly defined. In this study, we identify activation-induced cytidine deaminase (AID) as a non-canonical metabolic regulator that drives HCC progression through a self-reinforcing...

Jun-Na Jiao, Kai Zhang, Bai-Ge Li et al. · 0 citations
Jul 2026

p53 hotspot mutants attenuate CTL-mediated tumor cell killing through a novel ALKBH5-YTHDF3-PD-L1 pathway

It is found that the oncogenic effect of mutant p53 in vivo is dependent on the tumor immune microenvironment, and restoration of ALKBH5 activation or inhibition of the m6A modification-YTHDF3 axis could potentially reactivate immune surveillance and eliminate tumors harboring mut-p53.

Zhuan Ju, Xiang Zhang, Wen-Jie Zuo et al. · 0 citations

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