Targeted Intracellular Hydrogen Sulfide Delivery to Inflammatory Macrophages Reprograms Polarization and Mitigates Oxidative Stress in Osteoarthritis.
Osteoarthritis (OA) progression is driven by a chronic inflammatory microenvironment involving aberrant macrophage polarization and oxidative stress. Although the endogenous gasotransmitter hydrogen sulfide (H2S) possesses potent anti-inflammatory and antioxidant properties, its therapeutic application is hindered by r...