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Angela A. Sirna

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Open access Aug 2026

Targeting Mitochondrial Fission Produces Both Neuroprotective and Detrimental Effects in the SOD1 Mouse Model of Amyotrophic Lateral Sclerosis

The effects of Mdivi-1, a drug that inhibits mitochondrial fragmentation, in a mouse model of ALS showed that Mdivi-1 partially protected motor neurones in the spinal cord, but this did not result in improved motor performance.

Maria Ciuro, Chantal Rovetto, Angela A. Sirna et al. · 0 citations

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