Angelika Doetzlhofer

The RNA-binding protein TRIM71 Promotes Supporting Cell Reprogramming and Hair Cell Regeneration by Activating Sall4

These findings establish TRIM71 as an activator of HC regeneration in vivo, provide mechanistic insights into TRIM71’s role in SC reprogramming, and identify Sall4 as its essential effector in HC regeneration.

Loss of Zbtb20 disrupts cochlear supporting cell differentiation and maturation and extends the postnatal hair cell regenerative window in mice

CASZ1 regulates the maturation of outer hair cells and is required for hearing in mice

Summary The transcription factor ATOH1 is a master regulator of mechanosensory hair-cell (HC) development in the ear. Here, we report that its target gene Casz1 regulates the maturation of outer HCs (OHCs). Genetic deletion of Casz1 during (but not after) cochlear development in the mouse caused: hearing loss; disorgan...