Anguraj Moulishankar

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N‐Cinnamamide/Benzamide‐(4‐(Substituted Phenyl)‐6‐(4‐Cyclohexylphenyl)pyrimidin‐2‐Yl) Derivatives as EGFR Inhibitors Targeting EGFRWT , EGFRT790M , and EGFRL858R /T790M/C797S in NSCLC

A series of novel N‐Cinnamamide/benzamide‐(4‐(substituted phenyl)‐6‐(4‐cyclohexylphenyl)pyrimidin‐2‐yl) derivatives (Ri–Rxii) as EGFR inhibitors exhibited superior antiproliferative activity against wild‐type and mutant EGFR‐driven NSCLC cell lines, and was a strong candidate for overcoming drug resistance in NSCLC tre...