Anh T. Q. Cong

SV40 Large T antigen inhibits the host serine protease FAM111A through a zinc-dependent, cleavage-avoiding mechanism

The X-ray crystal structure of the FAM111A serine protease domain in complex with LT-C is reported, revealing the structural basis for direct inhibition of FAM111A and defining a zinc-dependent, cleavage-avoiding mechanism of protease inhibition that highlights an evolutionary arms race between SV40 and host antiviral proteases.