tRNA-derived fragments (tRFs) are a relatively recently discovered class of small RNAs implicated in gene-regulation, particularly behaving as microRNA to degrade target mRNAs with seed-sequence matches, but there have been very few reports of a clear phenotypic role of these small RNAs in cancer cell growth and other...
Fatemeh Esmaeili, Kumarjeet Banerjee, Ajay Chatrath et al.· Molecular Cancer Research· 0 citations
With advances in sequencing technologies and molecular tools, extrachromosomal circular DNA (eccDNA), once considered a mere by-product of genomic instability, is now recognized as playing important roles in genome plasticity, gene regulation, and cancer. In this review, we provide a comprehensive overview of eccDNA fr...
Saba Tufail, Anindya Dutta· Annual Review of Pathology· 0 citations
This study analyzed specific residues within the C-terminal α11 helix that are critical for stable association of Orc6 with the ORC complex in Drosophila and proposed that this NLS drives human protein to the nucleus and compensates for weaker Orc6-ORC(1-5) interactions by increasing the nuclear concentration of Orc6 a...
M. Balasov, Etsuko Shibata, Katarina Akhmetova et al.· bioRxiv· 0 citations
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