Concentration-Dependent Membrane Perturbation in DPPC Bilayers: Distinct Insertion Pathways, Stress Redistribution, and Mechanical Softening Induced by Chloroform and Alkanols
How do solute concentration and molecular chemistry govern the structural and mechanical response of lipid membranes? We address this using microsecond-scale molecular dynamics simulations of dipalmitoylphosphatidylcholine (DPPC) bilayers with chloroform (CHCl3) and a homologous series of alkanols (methanol, ethanol,...