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Open access Aug 2026

Temperature-driven isoform switching reprograms developmental gene expression in a human fungal pathogen

Post-transcriptional regulation is key to development, and yet little is known about how RNA isoform choice contributes to developmental choices in fungi. Here we assemble the first isoform-level transcriptome of Histoplasma, a ubiquitous human fungal pathogen that grows as an infectious environmental form (hyphae) or...

Murat C. Kalem, M. Voorhies, Natalie A. Markman et al. · 0 citations
Open access Sep 2026

Protoplasting and Transformation Using CRISPR/Cas9 in Coccidioides

Abstract Coccidioides posadasii and C. immitis are human fungal pathogens endemic to the American Southwest. C. posadasii and C. immitis are the causative agents of coccidioidomycosis, or Valley fever. They are pathogens of growing concern, as reported cases of coccidioidomycosis have increased 20‐fold in the last two...

Katrina M. Jackson, Matthew M. Morales, Edyta Szewczyk et al. · 0 citations

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