Next-generation azoles, such as oteseconazole and VT-1598, offer improved specificity for fungal sterol 14α-demethylase (CYP51) while reducing host toxicity, and new echinocandin derivatives, such as rezafungin, exhibit improved pharmacokinetics, enabling less frequent dosing.
Anjali Anil, A. Chakrabarti, Shivaprakash Mandya Rudramurthy· Microbiology and Infectious...· 0 citations
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