Open access
Sep 2026
N4BP1 uses tandem KH domains to associate with EDC4 and mRNA decapping factors in P-bodies
Processing bodies (P-bodies) are cytoplasmic, non-membrane-bound structures involved in mRNA decay. EDC4 serves as a key scaffold for the decapping complex within P-bodies. Here, we demonstrate that N4BP1 interacts with EDC4, as well as with DCP1A, DCP2, and XRN1 - key components of 5′-cap hydrolysis. Endogenous N4BP1...
P. Piłat, Ankur Garg, Udo Heinemann et al.
· Communications Biology · 0 citations