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Author

Anna Bianchi

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2 papers indexed here

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Sep 2026

Abstract A002: Transcriptional regulation and membrane sequestration of myeloid-derived TNF in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy defined by stromal desmoplasia, inflammation, and an immunosuppressive tumor microenvironment (TME) enriched for innate immune cells and characterized by effector T-cell dysfunction. Beyond malignant epithelial cells, the PDAC TME is composed predominantl...

Andrew Adams, H. Amirian, C. Rafie et al. · 0 citations
Sep 2026

Abstract B103: Interleukin-1 Receptor Accessory Protein (IL1RAP) is a Critical Determinant of Neutrophil Trafficking in Pancreatic Cancer

A dominant mechanism of chemoimmunotherapy resistance in PDAC is the robust infiltration and persistence of neutrophilic or polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). Interleukin-1 receptor accessory protein (IL1RAP) is the co-receptor for the IL-1 superfamily cytokines which drive inflammato...

Harper M. Marsh, Andrew Adams, H. Amirian et al. · 0 citations

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