Anna C. Pearson

Preserved social development but impaired executive function in a Shank3-deficient rat model of Phelan-McDermid syndrome

Rats with complete or partial Shank3 deficiency produce a selective behavioral profile in which high-order cognitive dysfunction is more pronounced than deficits in basic sensorimotor or select social behaviors, and these findings highlight executive dysfunction as a key consequence of the loss of Shank3.