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Author

Anna Delgado-Tejedor

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Open access Sep 2026

Systematic benchmarking of commercial workflows for isoform-resolved single-nucleus transcriptomics

This study provides a systematic assessment of four commercially available workflows for performing LR snRNA-seq and highlights key methodological trade-offs related to distinct library preparation strategies, thus providing practical guidance for future isoform-resolved transcriptome studies at the single-nucleus leve...

F. Köhler, Anna Delgado-Tejedor, Maik Zehnsdorf et al. · 0 citations
Open access Jul 2026

Single-molecule m6A profiling reveals position-dependent mRNA regulation and non-canonical roles for Ythdf2 in early embryogenesis

N nanopore direct RNA sequencing on zebrafish embryos across MZT is employed to resolve the interplay between m6A deposition, mRNA clearance, and poly(A) tail length dynamics at single-molecule resolution, and defines the single-molecule logic by which m6A modifications shape transcript fate during vertebrate MZT.

Sarah A. Alshawi, Anna Delgado-Tejedor, Srihari Madhavan et al. · 0 citations

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