Open access
Sep 2026
CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism
Epithelial ovarian cancer (EOC) is a highly lethal disease characterized by a high rate of platinum (PT)-resistant recurrence. Dysregulation of transcriptional and alternative splicing (AS) has been suggested as a possible mechanism of PT resistance involving transcriptional cyclin-dependent kinases (CDKs). We report t...
Ilenia Pellarin, Valentina Rossi, R. Margiotta et al.
· Signal Transduction and Targ... · 0 citations