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Capsid stabilization reprograms the nuclear fate of the HIV genome
Capsid stabilization, induced by low-nanomolar concentrations of Lenacapavir (LEN)—a first-in-class capsid inhibitor—impedes HIV-1 replication in macrophages without disrupting reverse transcription or nuclear import. In LEN-treated cells, ultrastructural analyses reveal preserved conical capsids persisting within nucl...