Abatacept for Prophylaxis of Acute and Chronic Graft-Versus-Host-Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation-A Systematic Review and Meta-Analysis of Cohort Studies.
BACKGROUND Graft-versus-host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T-cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited. PROCEDURE A systematic review and meta...