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Author

Anne E. van Vlimmeren

2 papers indexed here

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Review Open access Oct 2026

Sequence space exploration in SHP2: mechanistic insights from disease-associated mutations.

Multi-domain signaling proteins are regulatable switches that mediate signal transduction with high fidelity and selectivity in response to diverse cues. These proteins often harbor disease-associated mutations that disrupt their regulatory properties or interaction specificity to drive pathogenic signaling. Mapping se...

Anne E. van Vlimmeren, Zi-Yuan Jiang, Devon A. Semoy et al. · 0 citations
Open access Jul 2026

Identification of substrates of the protein tyrosine phosphatase PTP1B using in situ site-specific photo-crosslinking

The use of site-specific photo-crosslinking to covalently capture the substrates of tyrosine phosphatases in situ reveals previously unknown roles of PTP1B in signaling systems and could be readily extended to other tyrosine phosphatases in the same family.

Andrew C. Johns, Yethmie S. Goonatilleke, David C. Cabanero et al. · 0 citations

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