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Author

Anne-Laure Mallard de La Varende

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Open access Oct 2026

Biomarkers of subclinical cholestasis predict cancer immunotherapy outcomes

ABSTRACT In a recent paper published in Cancer Cell, we identified subclinical cholestasis as an accessible imprint of gut dysbiosis predicting resistance to immune checkpoint blockade. Our work connects γ-glutamyl transferase, bile-acid remodeling, and MAdCAM-1 loss to compromised antitumor immunity, opening avenues f...

Anne-Laure Mallard de La Varende, M. Fidelle, G. Kroemer et al. · 0 citations

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