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Anne-Laure Todeschini

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Open access Aug 2026

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs

It is shown that protein kinase C (PKC) phosphorylates FOXL2 in vitro, and hypothesized that PKC‐dependent phosphorylation within the FOXL2 DNA‐recognition helix would underlie a rapid, reversible switch, weakening DNA binding, redirecting subnuclear partitioning, and rewiring protein–protein interactions, thereby resh...

Ludovic Mousseron, Despoina-Maria Chousianiti, Francis Poulat et al. · 0 citations

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