Anne Wijnants

Gbp1 increases zebrafish susceptibility to mycobacterial infection by promoting macrophage pyroptotic cell death

Guanylate-binding proteins (GBP) are a family of interferon-inducible GTPases that operate via cell-autonomous immunity against intracellular pathogens and regulate cell death responses of infected host cells. GBPs have emerged as robust markers of human mycobacterial diseases, including tuberculosis and leprosy. H...