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Author

Anshika H. Motiani

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Open access Sep 2026

MHC restriction is structurally encoded by the T cell receptor germline

MHC restriction — the requirement for αβ T cell receptors (TCRs) to recognize Major Histocompatibility Complex (MHC) molecules when presenting peptide antigens — is a pillar of adaptive immunity. Here, we provide direct structural evidence for TCR germline-encoded recognition of MHC molecules irrespective of antigenic...

Nan Wang, Marta T. Borowska, K. Jude et al. · 0 citations
Jul 2026

Interrogating T-Cell Receptor Interactions with Peptide-MHC Through Structure-Guided Mutational Analysis 2219106

Studies have shown that germline contacts may underlie MHC restriction, supporting the idea that TCR—MHC specificity is partially encoded in the germline (Garcia et al., 1996; Marrack & Scott-Browne, 2010). In this study, we aimed to investigate how germline-encoded TCR contacts influence TCR—pMHC interactions an...

Anshika H. Motiani, Nan Wang, K. Christopher Garcia · 0 citations

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