Author

Anthony A. Grace

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Editorial Sep 2026

Hippocampal mechanisms and neural circuitry of negative symptoms in schizophrenia.

This work proposes a two-dimensional clinical framework for negative symptoms to better understand their neurobiological mechanism, by segregating symptoms into diminished expressivity and amotivation domains and explores how biological sex serves as a critical factor of individual variability in symptom expression.

D. Uliana, Anthony A. Grace · Schizophrenia Research · 0 citations

Review Jul 2026

Toward a Pluralistic Model for the Schizophrenia Spectrum-Dopamine and Beyond.

Dopaminergic hyperactivity may be a key mechanism for core psychotic symptoms in many patients, but it is unlikely that dopamine dysregulation is a universal final common pathway across symptom domains.

M. Keshavan, Henry A. Nasrallah, A. Abi-Dargham et al. · JAMA psychiatry · 0 citations