Author

Anthony J. Saviola

3 papers indexed here

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Open access Aug 2026

EphA4 Mediates Pro- and Antitumoral Effects Through Upstream Negative Regulation of AKT in Head and Neck Squamous Cell Carcinoma.

Head and Neck Head and Neck Squamous Cell Carcinoma (HNSCC) is driven by an immunosuppressive tumor microenvironment (TME). We examined the immune-modulatory role of EphA4 in HNSCC using spatial analysis, multi-compartment RNA-sequencing from Oral Cavity Squamous Cell Carcinoma (OCSCC), and three genetically engineered...

S. Corbo, Khalid N. M. Abdelazeem, D. Nguyen et al. · Cancer immunology research · 0 citations

Open access Jul 2026

N-terminal processing unlocks global dynamics for substrate engagement in Spl proteases

Dynamic allostery is established as the mechanism of N-terminal activation in this subclass of serine proteases in a pathogenic methicillin-resistant S. aureus strain and mutational perturbation of this dynamic network modulates substrate engagement and catalytic activity in a manner consistent with dynamic control of...

Eunjeong Lee, J. Redzic, Samrat Sarkar et al. · Science Advances · 0 citations

Open access Aug 2026

Structural and Functional Interrogation of Active Streptococcus pneumoniae Sortase A

Sortase A (SrtA) enzymes covalently anchor surface proteins to Gram-positive bacterial cell walls, promoting colonization and virulence. In Streptococcus pneumoniae, previous studies identified both a domain-swapped dimer and an active refolded monomer, but the active enzyme has not been characterized at the structural...

Eunjeong Lee, Blaine H. Gordon, J. Redzic et al. · Biomolecules · 0 citations