Open access
Aug 2026
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
The findings establish the retina as an early site of AD synaptopathy and position UCHL1 as a candidate biomarker and mechanistic mediator linking amyloid pathology, neuroinflammation, and synaptic vulnerability.
A. Rentsendorj, Jean-Philippe Vit, Alexandre Hutton et al.
· Advancement of science · 0 citations