Junín virus (JUNV) is the causative agent of Argentine Hemorrhagic Fever (AHF) with the capacity for human-to-human transmission. AHF is endemic to Argentina and is prevented in at-risk populations with the regionally approved Candid#1 live attenuated vaccine (JUNV/C#1). However, there are barriers to US FDA (Fed...
Sharon Jan, Christopher A. Sumner, Grecia Sandoval et al.· Antibody Therapeutics· 0 citations
ABSTRACT Argentine hemorrhagic fever (AHF) is a disease caused by the Junín virus (JUNV) that can be fatal in 15%–30% of untreated cases. Although JUNV is the only arenavirus for which efficient therapy and vaccination have been established, its administration is limited. In this study, hybridoma technology was used to...
Traditional in vitro screening of a nanobody library combined with an intracellular bioluminescence resonant energy transfer (BRET) proximity sensor approach for sequence down-selection can yield strong in vitro binders that also perform well as intrabodies, in this case capable of binding to and inhibiting the enzymat...
J. Wang, Victor L. Lam, E. Dunn et al.· bioRxiv· 0 citations
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