SAR and mechanistic pathways of oxadiazole derivatives: targeting enzymes for antidiabetic therapy.
The global prevalence of diabetes mellitus continues to rise sharply, creating an urgent need for effective strategies to manage postprandial hyperglycemia. Inhibition of the carbohydrate-hydrolysing enzymes α-glucosidase and α-amylase is a well-established approach for reducing glucose absorption and improving glycaem...