Reclassification of Noncanonical MET Splice-Site Variants Using RNA-Based Validation: A Practical Diagnostic Approach in Non-Small Cell Lung Cancer.
MET exon 14 (METex14) skipping alterations represent actionable oncogenic drivers in non-small cell lung cancer (NSCLC). However, noncanonical intronic splice-site variants are frequently classified as variants of uncertain significance (VUS) on DNA-based next-generation sequencing (NGS), limiting timely therapeutic de...