Baicalein targets the Nrf2/Keap1 interaction and related stress pathways to mitigate drug-induced toxicity and reverse resistance in breast cancer: A review.
The cellular stress mediator Nrf2 and its negative regulator Keap1 are frequently dysregulated across breast cancer subtypes. As a master regulator of stress-related pathways, the Nrf2/Keap1 complex drives either cytoprotection or cell death, depending on the cellular context. Furthermore, its roles in promoting drug r...