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Author

Aojiasi Hashan

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Open access Sep 2026

A bispecific antibody targeting a membrane-proximal ASGPR1 region promotes TNF-α recruitment and uptake

Recruiting an endocytic receptor through an antibody offers a route to redirect extracellular cytokines into cells. Here, we developed BiAb-J31, an IgG-like bispecific antibody linking TNF-α recognition to a membrane-proximal region of asialoglycoprotein receptor 1 (ASGPR1). J31 was isolated by immunization with an eng...

Xue-Bo Song, Si-Jie Li, Aojiasi Hashan et al. · 0 citations

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