A bispecific antibody targeting a membrane-proximal ASGPR1 region promotes TNF-α recruitment and uptake
Recruiting an endocytic receptor through an antibody offers a route to redirect extracellular cytokines into cells. Here, we developed BiAb-J31, an IgG-like bispecific antibody linking TNF-α recognition to a membrane-proximal region of asialoglycoprotein receptor 1 (ASGPR1). J31 was isolated by immunization with an eng...