Open access
Jul 2026
Neutrophil extracellular traps induced by tumour-derived NGAL reprogram CAF subtypes via ITGA5 to promote tumour progression in pancreatic cancer
An IL-17/NGAL/NETs/ITGA5 axis linking neutrophil-derived extracellular DNA to iCAF specification and immunosuppression in PDAC is defined, providing a rationale for combinatorial immunotherapy.
Wanli Liu, Xian-Ze Wang, Ren-Yu Chen et al.
· Gut · 0 citations