USP13-SKP2-P57/kip2 Axis Mediates Spautin-1 Induced Transcriptional Upregulation of NURR1: Implications for NURR1 Mediated Neurotrophic Activity.
The progressive loss of midbrain dopamine neurons leading to motor deficits is the primary cause of Parkinson's disease (PD). Emerging reports on the role of NURR1 in the differentiation and maintenance of dopamine neurons; the association of reduced levels/familial mutants of NURR1 in PD subjects makes it a promising...