This work presents the first fully automated HDX−MS platform incorporating a two-stage delipidation workflow and underscores the importance of studying membrane proteins in native lipid environments.
Charlotte Guffick, J. R. Rincon Pabon, Damon Griffiths et al.· Analytical Chemistry· 0 citations
HDX-MS analysis of membrane protein–lipid interactions is discussed, particularly key challenges such as lipid-induced ion suppression and chromatographic interference, and recent advances in lipid removal strategies, subzero chromatography, mass spectrometry/ion mobility, and the integration of molecular dynamics simu...
Artemis Lioupi, Agni F. M. Gavriilidou, Argyris Politis· Chemical Science· 0 citations
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