PACM-03 TUMOR–BRAIN CROSSTALK DRIVES NEURAL MICROENVIRONMENT REMODELING AND PROMOTE DEMYELINATION IN BRAIN METASTASES
It is demonstrated that BM actively disrupt myelin homeostasis and neural signaling within surrounding brain tissue, and this ex-vivo platform provides a robust experimental system to study tumor–brain interactions and to evaluate therapeutic strategies aimed at limiting tumor-induced neurological damage.