Aug 2026
Design of fluorinated triazinoindoles as highly potent and markedly selective ALR2 inhibitors: synthesis, in silico and in vitro evaluation of promising lead compounds.
Aldose reductase (ALR2) is widely recognized as a therapeutic target for diabetic complications and is involved in the metabolism of reactive aldehydes generated during hyperglycemia and lipid peroxidation. To investigate the effect of fluorination on inhibitory potency and enzyme selectivity, we designed and synthesiz...
L. Kováčiková, Terezia Teplanova, M. Májeková et al.
· Bioorganic chemistry (Print) · 0 citations