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The main aim of this review is to give an overview of the journey of evolution, different approaches, limitations, advances and future development for immunotherapy in cancer treatment.
Current evidence for molecular and cellular mechanisms underlying neuroblastoma initiation, progression, and therapeutic resistance is examined, with a focus on MYCN amplification, ALK pathway dysregulation, chromosomal instability, telomere maintenance mechanisms, epigenetic remodeling, and neural crest developmental...
Key aging‐related mechanisms, including genomic instability, telomere attrition, cellular senescence, chronic inflammation, chronic inflammation (inflammaging), and immune system decline, all of which create a tumor‐permissive environment are explored.
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