Review
Open access
Aug 2026
Characterizing the molecular mechanisms underlying aluminium-induced disruptions in neuronal survival pathways
Substantial changes in key signalling pathways, such as the IL-1β/JNK, PI3K/Akt/mTOR, Nrf2/Ho-1, System Xc-/GPX4, and NLRP3 inflammasome activation pathways, were observed and highlight aluminium as a potent modulator of neuronal survival pathways, driving neurodegeneration through multifactorial mechanisms.
K. Sravya, Arpitha Rao, P. Harshitha et al.
· Metabolic brain disease · 0 citations