Open access
Jul 2026
Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3.
A pathogenic role for repeat expansion-driven peripheral nerve degeneration in SCA3 is defined, sensory neurons are identified as key therapeutic targets, and a preclinical platform for developing peripheral interventions in SCA3 and related repeat expansion disorders is provided.
Juan P Mato, John M. Hayes, Jacen Emerson et al.
· Annals of Neurology · 0 citations